THC-O Acetate is a synthetic Cannabis that has been found in products sold as legal highs. It was first identified in 2013 in a product called “K2 Summit.” THC-O Acetate is a potent agonist of the cannabinoid receptor 1 (CB1) and has been shown to produce psychoactive effects similar to those produced by Δ9-tetrahydrocannabinol, or